Job Description

Temp Senior Research Associate, Cancer Immunology
The Opportunity:

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  As a key player in our Cancer Immunology team, you will:
  
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  Use immunology techniques to perform cutting-edge studies,  in vitro and  ex vivo , to interrogate key scientific questions about established or candidate drug targets and therapeutic mechanisms
  
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  Support immune biomarker identification to inform patient selection for monotherapy and combination therapy strategies
  
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  Collaborate with biochemists, cell biologists and pharmacologists and other members of the team to generate new models and novel insights that fuel drug development
  
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  Manage and analyze experimental data and present experimental results at internal meetings and scientific conferences
  

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  In this lab-based role, you will:
  
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  Execute experimental strategies, using cellular and molecular immunological techniques, to investigate target biology and therapeutic mechanisms of action in  in vitro and  ex viv o immuno-oncology models
  
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  Expand our immune-based assay toolbox by implementing new technologies
  

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  Bachelor’s degree or Master’s degree in Science with 4+ years of experience in a cell biology/cellular assay development role. Title will be adjusted according to experience.
  
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  Deep expertise with mammalian cell culture across a variety of cell types (primary and immortalized) and growth conditions. Demonstrated experience handling (maintaining, passaging, plating) multiple cell lines at once.
  
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  Hands-on experience with a wide range of cellular assay techniques (including, but not limited to, Flow Cytometry, Western Blot, MSD, qPCR) suitable for target identification and/or compound characterization.
  
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  Rigorous, quantitative, attention to detail, keen to maximize efficiency.
  
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  Highly organized, and excellent record keeping skills.
  
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  Excellent written and verbal communication skills to facilitate collaboration with project and departmental teams.
  
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  Innovative, proactive team-player with high energy who will thrive in our fast-paced drug discovery and development environment.
  

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  Immuno-oncology assays such as T cell proliferation, suppression and killing assays, antigen presentation assays, phagocytosis assays, etc.
  
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  Experience with primary immune cells, including human PBMC handling, isolation and differentiation.
  
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  Incucyte cell-based assays.
  
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  Ex vivo experiments, including murine tissue collection, dissociation, and processing for downstream applications.
  

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